https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 The MSReactor computerized cognitive battery correlates with the processing speed test in relapsing-remitting multiple sclerosis https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:39575 Wed 27 Jul 2022 14:43:55 AEST ]]> Sun exposure across the life course significantly modulates early multiple sclerosis clinical course https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47544 Wed 22 Mar 2023 15:52:30 AEDT ]]> Patient-determined disease steps is not interchangeable with the Expanded Disease Status Scale in mild to moderate multiple sclerosis https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54397 Wed 21 Feb 2024 15:48:45 AEDT ]]> Interleukin-6 gene promoter-572 C allele may play a role in rate of disease progression in multiple sclerosis https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24220 A and −174 G>C) correlate with MS susceptibility, but with varying results. In the present study, we analyzed these polymorphisms, together with an additional polymorphism (−572 G>C) in 279 healthy controls and 509 patients with MS. We found no significant differences between MS patients and healthy controls for the different −597 or −174 IL6 promoter alleles or genotypes. There was a slight reduction in the percentage of individuals with MS who carried a C allele at position −572, although this was not significant after correction for multiple comparisons. Interestingly, however, the −572 C allele showed a significant correlation with the MS severity score, suggesting a possible role in disease progression.]]> Wed 11 Apr 2018 15:18:27 AEST ]]> The MS risk allele of CD40 is associated with reduced cell-membrane bound expression in antigen presenting cells: implications for gene function https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:26643 Wed 11 Apr 2018 13:39:49 AEST ]]> The effect of emerging nutraceutical interventions for clinical and biological outcomes in multiple sclerosis: A systematic review https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:39853 Tue 26 Jul 2022 10:28:34 AEST ]]> Midsagittal corpus callosum area and conversion to multiple sclerosis after clinically isolated syndrome: a multicentre Australian cohort study https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34120 Tue 12 Feb 2019 13:13:57 AEDT ]]> The CYP27B1 variant associated with an increased risk of autoimmune disease is underexpressed in tolerizing dendritic cells https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:19680 Sat 24 Mar 2018 07:53:39 AEDT ]]> Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:23578 −4). In a replication phase, we combined these data with previous genome-wide association study (GWAS) data from an independent 14,802 subjects with multiple sclerosis and 26,703 healthy controls. In these 80,094 individuals of European ancestry, we identified 48 new susceptibility variants (P < 5.0 x 10−8), 3 of which we found after conditioning on previously identified variants. Thus, there are now 110 established multiple sclerosis risk variants at 103 discrete loci outside of the major histocompatibility complex. With high-resolution Bayesian fine mapping, we identified five regions where one variant accounted for more than 50% of the posterior probability of association. This study enhances the catalog of multiple sclerosis risk variants and illustrates the value of fine mapping in the resolution of GWAS signals.]]> Sat 24 Mar 2018 07:12:44 AEDT ]]> Association between cognitive trajectories and disability progression in patients with relapsing-remitting multiple sclerosis https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46218 Mon 14 Nov 2022 12:12:01 AEDT ]]> Longitudinal epidemiology of multiple sclerosis in Townsville, Queensland, Australia, 2012-2022 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54178 Mon 12 Feb 2024 13:11:52 AEDT ]]> Examining the environmental risk factors of progressive-onset and relapsing-onset multiple sclerosis: recruitment challenges, potential bias, and statistical strategies https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53931 Fri 22 Mar 2024 08:23:10 AEDT ]]>